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avivasysbio/ZAP70 Antibody (Phospho-Tyr315) (OASG07611)/100 uL/OASG07611

avivasysbio/ZAP70 Antibody (Phospho-Tyr315) (OASG07611)/100 uL/OASG07611
  • avivasysbio/ZAP70 Antibody (Phospho-Tyr315) (OASG07611)/100 uL/OASG07611
商品介绍
Predicted Species Reactivity:
Human, Mouse
Product Format:
Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
WB, IHC, ELISA
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Gene Symbol:
ZAP70
Official Gene Full Name:
zeta-chain (TCR) associated protein kinase 70kDa
NCBI Gene Id:
7535; 22637;
Swissprot Id:
P43403, P43404
Alias Symbols:
ZAP70, SRK, Tyrosine-protein kinase ZAP-70, 70 kDa zeta-chain associated protein, Syk-related tyrosine kinase
Replacement Item:
This antibody may replace item sc-101822 from Santa Cruz Biotechnology.
Description of Target:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Molecular Weight:
60 kDa
Purification:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ZAP70.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ZAP70.
Immunogen:
Synthesized peptide derived from human ZAP-70 around the phosphorylation site of Y315. Location: 250-330aa.
Concentration:
1 mg/ml
Datasheets/Manuals:
Printable datasheet for anti-ZAP70 (OASG07611) antibody
Target Post-Translational Modification:
Phospho-Tyr315
Specificity:
Phospho-ZAP-70 (Tyr315) Polyclonal Antibody detects endogenous levels of ZAP-70 protein only when phosphorylated at Y315.
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